Study on diagnosis of early Alzheimer's disease by β-amyloid imaging(BF227).

受试者为东北大学招募的15名认知正常受试者（NL）、20名轻度认知障碍（MCI）患者和21名阿尔茨海默病（AD）患者。他们接受了BF 227-PET，3D-MRI和神经心理学检查。VBM-MRI显示AD组灰质体积最小，MCI组次之，NL组最小。有人认为，这一结果对应于AD发展的每个阶段。相比之下，对于BF 227-PET上的Aβ沉积，AD和MCI显示出显著高于NL的积累。Aβ沉积在AD和MCI之间无显著差异。这一事实表明，Aβ沉积在MCI的一个阶段已经达到平台。此外，在神经心理学检查方面，灰质丢失可能影响认知功能，而Aβ沉积至少在AD发病时可能不影响认知功能。

The subjects were 15 cognitively normal subjects(NL), 20 patients with mild cognitive impairment(MCI) and 21 patients with Alzheimer disease(AD) recruited in Tohoku University. They underwent BF227-PET, 3D-MRI, and neuropsychological examination. The gray matter volume on VBM-MRI was lowest in the AD, followed by MCI, and NL. It has been suggested that this results correspond in each stage in the development of AD. In contrast, as for Aβ deposition on BF227-PET, AD and MCI showed significantly higher accumulation than NL. No significant differences were observed between AD and MCI in the Aβ deposition. The fact suggests that the Aβ deposition already reached a plateau in a stage of MCI. Moreover, in the relation with neuropsychological examination, gray matter loss may influence the cognitive function, however, the Aβ deposition may not influence the cognitive function at least in AD onset.