Study on diagnosis of early Alzheimer's disease by β-amyloid imaging(BF227).

研究对象为日本东北大学招募的15名认知正常受试者（NL）、20名轻度认知障碍患者（MCI）和21名阿尔茨海默病（AD）患者。接受BF227-PET、3D-MRI和神经心理学检查。VBM-MRI显示的灰质体积在AD中最低，其次是MCI和NL。有人认为，这一结果在阿尔茨海默病发展的每个阶段都是一致的。相比之下，AD和MCI在BF227-PET上的Aβ沉积量明显高于NL。AD和MCI在Aβ沉积方面无显著差异。这表明a β沉积在MCI阶段已经达到平台期。此外，在与神经心理检查的关系中，灰质损失可能影响认知功能，但至少在AD发病时，Aβ沉积可能不影响认知功能。

The subjects were 15 cognitively normal subjects(NL), 20 patients with mild cognitive impairment(MCI) and 21 patients with Alzheimer disease(AD) recruited in Tohoku University. They underwent BF227-PET, 3D-MRI, and neuropsychological examination. The gray matter volume on VBM-MRI was lowest in the AD, followed by MCI, and NL. It has been suggested that this results correspond in each stage in the development of AD. In contrast, as for Aβ deposition on BF227-PET, AD and MCI showed significantly higher accumulation than NL. No significant differences were observed between AD and MCI in the Aβ deposition. The fact suggests that the Aβ deposition already reached a plateau in a stage of MCI. Moreover, in the relation with neuropsychological examination, gray matter loss may influence the cognitive function, however, the Aβ deposition may not influence the cognitive function at least in AD onset.