Study on diagnosis of early Alzheimer's disease by β-amyloid imaging(BF227).

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The subjects were 15 cognitively normal subjects(NL), 20 patients with mild cognitive impairment(MCI) and 21 patients with Alzheimer disease(AD) recruited in Tohoku University. They underwent BF227-PET, 3D-MRI, and neuropsychological examination. The gray matter volume on VBM-MRI was lowest in the AD, followed by MCI, and NL. It has been suggested that this results correspond in each stage in the development of AD. In contrast, as for Aβ deposition on BF227-PET, AD and MCI showed significantly higher accumulation than NL. No significant differences were observed between AD and MCI in the Aβ deposition. The fact suggests that the Aβ deposition already reached a plateau in a stage of MCI. Moreover, in the relation with neuropsychological examination, gray matter loss may influence the cognitive function, however, the Aβ deposition may not influence the cognitive function at least in AD onset.