How much can reduction of contrast agent is possible in angiography?

血管造影中造影剂的用量可以减少多少？

• 批准号: 20591471
• 负责人: MATSUSHITA Shonosuke
• 金额: $ 2.91万
• 依托单位: University of Tsukuba
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20591471/
• 关键词: HARP受像管; ラット; 単色X線; 希釈造影剤; 放射光; 血管造影; 造影剤; 造影剤腎症

Contrast material is essentially employed in angiography. Contrast material-induced nephropathy (CIN) is developed in dose-dependence manner. Recently, the doses of contrast material in angiography tend to increase due to frequent application of stent therapy. On the other hand, the its dose is limited for the preservation of renal function. To solve this, we thought that the combination of synchrotron radiation angiography and high sensitive HARP receiver may make it possible to reduce the dose of contrast material. In vitro examination, synchrotron radiation angiography with HARP receiver was able to identify 2% concentration of iodine contained contrast material. In vivo examination using rat angiography in lower extremity, 8% concentration of contrast material was statistically equivalent to 32% concentration of contrast material in counting the number of vascular branches. It means that a quarter of concentration in contrast material can be effectively used, if this proposed angiographic system is utilized.

造影剂主要用于血管造影术。造影剂肾病（CIN）的发生呈剂量依赖性。近年来，由于支架治疗的频繁应用，血管造影中造影剂的剂量趋于增加。另一方面，其剂量是有限的，以保护肾功能。为了解决这个问题，我们认为同步辐射血管造影术和高灵敏度HARP接收器的结合可能会减少造影剂的剂量。在体外实验中，同步辐射血管造影与HARP接收器能够识别浓度为2%的含碘造影剂。在体大鼠下肢血管造影检查中，8%浓度的造影剂与32%浓度的造影剂在统计学上等同于计数血管分支数。这意味着，如果使用所提出的血管造影系统，则可以有效地使用造影剂中的四分之一浓度。

项目成果

Examination of a new angiographic system with a highly sensitive receiver and synchrotron radiation for reducing the dose of contrast medium

检查具有高灵敏度接收器和同步加速器辐射的新型血管造影系统，以减少造影剂剂量

• 发表时间: 2011
• 期刊: American Journal of Roentgenology
• 影响因子: 5
• 作者: Konishi T;Matsushita S;Sakakibara;et al.
• 通讯作者: et al.

Erythropoietin enhances arterioles more significantly than it does capillaries in an infarct rat heart model.

在梗塞大鼠心脏模型中，促红细胞生成素对小动脉的增强作用比对毛细血管的作用更显着。

• 发表时间: 2009
• 期刊: Int.Heart J 50(6)
• 作者: T.Imazuru;S.Matsushita;K.Hyodo;他
• 通讯作者: 他

Cardiac sympathetic activity assessed by heart rate variability indicates myocardial ischemia on cold exposure in diabetes

通过心率变异性评估的心脏交感神经活动表明糖尿病患者冷暴露时心肌缺血

• 发表时间: 2010
• 作者: K.Sasaki;S.Matsushita;Y.Sakakibara
• 通讯作者: Y.Sakakibara

Examination of a new angiographic system with a highly sensitive receiver and synchrotron radiation for reducing the dose of contrast medium.

检查具有高灵敏度接收器和同步加速器辐射的新型血管造影系统，以减少造影剂的剂量。

• 发表时间: 2011
• 期刊: American Journal of Roentgenology (in press)
• 作者: Konishi T;Matsushita S;Hyodo K;Aikawa S;Tokunaga C;Enomoto Y;Kanemoto S;Sato F;Hiramatsu Y;Sakakibara Y
• 通讯作者: Sakakibara Y

FOP-HARP撮像管とその医療応用

FOP-HARP显像管及其医疗应用

• 发表时间: 2009
• 作者: 宮川和典;大川裕司;松原智樹;菊地健司;鈴木四郎;谷岡健吉;久保田節;江上典文;渥美卓治;松下昌之助;小西泰介;榊原謙;兵藤一行
• 通讯作者: 兵藤一行