How much can reduction of contrast agent is possible in angiography?

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Contrast material is essentially employed in angiography. Contrast material-induced nephropathy (CIN) is developed in dose-dependence manner. Recently, the doses of contrast material in angiography tend to increase due to frequent application of stent therapy. On the other hand, the its dose is limited for the preservation of renal function. To solve this, we thought that the combination of synchrotron radiation angiography and high sensitive HARP receiver may make it possible to reduce the dose of contrast material. In vitro examination, synchrotron radiation angiography with HARP receiver was able to identify 2% concentration of iodine contained contrast material. In vivo examination using rat angiography in lower extremity, 8% concentration of contrast material was statistically equivalent to 32% concentration of contrast material in counting the number of vascular branches. It means that a quarter of concentration in contrast material can be effectively used, if this proposed angiographic system is utilized.