The development of the human TNFα monoclonal antibody therapy for non-alcoholic steatohepatitis after the preoperative chemotherapy

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We made a NASH model after the chemotherapy in C57BL/6 mouse and the SD rat, adjusted by the medication number of times of Irinotecan, applied dose and the administration period of Colin deficiency amino acid food. But, the occurrence of NASH wasn't recognized in macroscopilally, and microscopical findings of the adiposity of the liver, the inflammation, and the fibrosis. Our models were no differences for a group of control in the serum transaminase level, the serum lipid, TNFα and IL6, either.