The Cardioprotective Effect of Bone Marrow Stem Cells in the Late Phase of Ischemic Preconditioning

骨髓干细胞在缺血预适应后期的心脏保护作用

• 批准号: 20591648
• 负责人: MORIKAGE Noriyasu
• 金额: $ 2.91万
• 依托单位: Yamaguchi University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20591648/
• 关键词: Ischemic preconditioning; 虚血再灌流障害; 幹細胞; 骨髄幹細胞; 虚血プレコンディショニング; Ischemic Preconditioning

Ischemic preconditioning is an innate phenomenon in which brief exposure to sublethal ischemia provides tissue protection from ischemia/reperfusion injury. But the precise mechanisms of organ protection by ischemic preconditioning are unclear. This study shows that the enhanced mobilization and recruitment of bone marrow stem cells play an important role in the late phase of ischemic preconditioning.

缺血预适应是一种先天现象，其中短暂暴露于亚致死缺血可提供组织免受缺血/再灌注损伤。但缺血预处理保护器官的确切机制尚不清楚。这项研究表明，增强骨髓干细胞的动员和募集在缺血预适应的后期发挥着重要作用。

项目成果

Ischemic Pre-Conditioning Enhances the Mobilization and Recruitment of Bone Marrow Stem Cells to Protect Against Ischemia/Reperfusion Injury in the Late Phase

• DOI: 10.1016/j.jacc.2009.02.015
• 发表时间: 2009-05-12
• 期刊: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
• 影响因子: 24
• 作者: Kamota, Takahiro;Li, Tao-Sheng;Hamano, Kimikazu
• 通讯作者: Hamano, Kimikazu

Myocardial repair achieved by the intramyocardial implantation of adult cardiomyocytes in combination with bone marrow cells

• DOI: 10.3727/096368908786092702
• 发表时间: 2008-01-01
• 期刊: CELL TRANSPLANTATION
• 影响因子: 3.3
• 作者: Li, Tao-Sheng;Takahashi, Masaya;Hamano, Kimikazu
• 通讯作者: Hamano, Kimikazu

虚血プレコンディショニングによる心筋保護効果における骨髄幹細胞の関与

骨髓干细胞参与缺血预处理的心肌保护作用

• 发表时间: 2010
• 作者: 鴨田隆弘;李桃生;濱野公一
• 通讯作者: 濱野公一

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