The basic research on HIF-1-targeted cancer therapy

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In this study, we examined the possibility that hypoxia in tumor tissues might be implicated in the immunosuppression in tumor-bearing host. Based on the data that hypoxia-inducible factor-1 (HIF-1) regulates expressions of many genes associated with tumor progression, we hypothesized that inhibition of HIF-1 in tumor tissues would augment anti-tumor immune responses. Tumor-bearing mice were administered HIF-1 inhibitor into the established tumor, and then, anti-tumor immune responses elicited in the mice were examined. As results, HIF-1 inhibition attenuated the level of TGF-beta in tumor tissues. In tumor-draining lymph nodes and spleen, the numbers of regulatory cells were decreased. In spleen, antigen-specific effector cells were increased