Myocardial protection for normothermic ischemia and reperfusion in immature heart : effect of mitochondria permeability transition pore inhibitor.

异丙酚在缺血再灌注过程中抑制线粒体通透性过渡孔（MPTP），可能具有心肌保护作用，被广泛用作麻醉剂。在本研究中，我们研究了异丙酚是否对未成熟心脏常温缺血再灌注有保护作用。这项研究是在Langendorff模型中使用未成熟的兔子心脏进行的。异丙酚在浓度为1 ~ 4μg/ml时具有保护作用，以2μg/ml时保护效果最好。从心脏功能恢复的角度来看，2μg/ml的保护作用与环孢素（另一种MPTP抑制剂）相当。然而，我们也观察到在4μg/ml或更高浓度时显著的负性肌力效应，在10μg/ml或更高浓度时，这种副作用是至关重要的。

Propofol, which is widely used as an anesthetic agent, inhibits the mitochondria permeability transition pore(MPTP) during reperfusion after ischemia and may work for myocardial protection. In the present study, we investigated whether propofol would protect the immature heart during normothermic ischemia and reperfusion. The study was carried out by using immature rabbit hearts in the Langendorff model. Propofol showed protective effect at concentrations of 1-4μg/ml, and the best protection was at 2μg/ml. The protection at 2μg/ml was equal to that of cyclosporine(another MPTP inhibitor) in a viewpoint of functional recovery of the heart. However, we also observed significant negative inotropic effect at 4μg/ml or higher concentrations and this side effect was crucial at 10μg/ml or higher.