Analysis on invasion and metastasis of lung adenocarcinomas with micropapillary pattern.

为了分析肺腺癌微乳头状形态（MPP）与血管内皮生长因子（VEGF）的关系，我们收集了517例肺癌切除术患者并进行了临床病理研究。MPP阳性肺癌表现为预后差，多发血管侵犯，多发淋巴结转移。免疫组化，VEGF-C和R3在MPP部位强烈表达。通过小鼠模型分析，认为VEGFR-1和vegfr - 2在间质组织肿瘤进展中起重要作用。

To analyze the relationship between lung adenocarcinomas with micropapillary pattern (MPP) and vascular endothelial growth factors (VEGF), 517 cases of resected lung cancers were collected and clinic-pathologic study was performed. MPP- positive lung cancers revealed poor prognosis, frequent vascular invasion, and frequent lymph node metastasis. Immunohistochemically, VEGF-C and R3 strongly expressed in MPP portions. By the analysis on mice models, it was considered that VEGFR-1 and 2 plays an important role in tumor progression on the stromal tissue.