Analysis on invasion and metastasis of lung adenocarcinomas with micropapillary pattern.

点击翻译按钮获取中文摘要

To analyze the relationship between lung adenocarcinomas with micropapillary pattern (MPP) and vascular endothelial growth factors (VEGF), 517 cases of resected lung cancers were collected and clinic-pathologic study was performed. MPP- positive lung cancers revealed poor prognosis, frequent vascular invasion, and frequent lymph node metastasis. Immunohistochemically, VEGF-C and R3 strongly expressed in MPP portions. By the analysis on mice models, it was considered that VEGFR-1 and 2 plays an important role in tumor progression on the stromal tissue.