A examination of KGF seat to prevent bronchpleural fistula.

KGF座检查预防支气管胸膜瘘。

• 批准号: 20591673
• 负责人: NAGAYASU Takeshi
• 金额: $ 2.75万
• 依托单位: Nagasaki University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20591673/
• 关键词: KGF; 気管軟骨; 創傷治癒; 代償性肺肥大; 肺移植; 人工気管

Local administration of KGF to trachea wound could not enhance the healing of trachea cartilage. On the other hand, intratraheal administration of KGF enhanced pulmonary epithelial proliferation in post-trilobectomy rat lung. Intratracheal administration of KGF in the remaining lung significantly augmented PCNA of alveolar cell. High dose single injection and low dose daily injection were so effective. Our results implicate that Intratracheal administration of KGF significantly augmented lung epithelial proliferation in compensatory growth in the remaining lung after trilobectomy in rats.

气管创面局部应用KGF不能促进气管软骨的愈合。另一方面，气管内给予KGF可增强三叶切除后大鼠肺上皮细胞的增殖。在剩余肺中气管内给予KGF可显著增加肺泡细胞的PCNA。高剂量单次注射和低剂量每日注射均有效。我们的研究结果表明，气管内给予KGF可显著增强三叶切除后剩余肺代偿性生长的肺上皮增殖。