The effect of gultamate receptor agonist on cerebral microcirculation and to appearance of AQP-4 in perivascular area during various anesthetic state.

不同麻醉状态下谷氨酸受体激动剂对脑微循环及血管周围区域AQP-4出现的影响。

• 批准号: 20591799
• 负责人: OHATA Hiroto
• 金额: $ 1.83万
• 依托单位: Gifu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20591799/
• 关键词: グルタミン酸受容体作動薬; AMPA; 脳微小循環; AQP-4; 高二酸化炭素血症; ラット; グルタミン酸受容体; アクアポリン; 全身麻酔薬; アクアポリン-4; セボフルラン; プロポフォール

To examine whether anesthetic agents as well as drugs used during general anesthesia could affect cerebral microcirculation induced by gulutamate receptor agonists, especially AMPA, and could affect an appearance of water channel AQP-4 concentrated in astrocyte of perivascular areas in rat brain.AMPA-induced dilation of pial arterioles in rats was observed all anesthetic agents (isoflurane, sevoflurane, propofol, and dexmedetomidine), whereas the dilatory response to AMPA anesthetized with intravenous anesthetics was smaller than that of inhalational anesthetics.We could not observe the differences of localization to AQP-4 among anesthetic agents in rat cortical brain slices superfused with AMPA.The results of this study suggested that cellular mechanisms underlying functional hyperemia might be affected by the type of general anesthetics, however water metabolism in glial cells might be unchanged during functional hyperemia in rat brain.

[目的]探讨麻醉剂和全麻中使用的药物是否会影响古鲁他明受体激动剂，尤其是AMPA诱导的脑微循环，以及对集中在大鼠脑血管周围星形胶质细胞中的水通道AQP-4的出现的影响。而静脉麻醉药麻醉的AMPA对AQP-4的扩张反应小于吸入麻醉药。我们没有观察到不同麻醉剂对AQP-4的定位差异。本研究结果提示，功能性充血的细胞机制可能受全麻药类型的影响，但在大鼠脑功能充血过程中，胶质细胞的水代谢可能没有变化。

项目成果

Onset of pulmonary ventilation in fetal sheep produces pial arteriolar constriction dependent on cytochrome p450 ω-hydroxylase activity.

胎羊肺通气的开始产生依赖于细胞色素 p450 ω-羟化酶活性的软脑膜小动脉收缩。

• 发表时间: 2010
• 期刊: J Appl Physiol 109
• 作者: Ohata H;Gebremedhin D;Narayanan J;Harder DR;Koehler RC.
• 通讯作者: Koehler RC.

抗NMDA受容体脳炎患者の卵巣奇形腫摘出術の麻酔管理

抗NMDA受体脑炎患者卵巢畸胎瘤切除术的麻醉管理

• 发表时间: 2010
• 作者: 大畠博人;飯田祐子;鬼頭和裕;河村三千香;山下実華;太田宗一郎
• 通讯作者: 太田宗一郎

Role of niric oxide in cerobrovascular reactivity to NMDA and hypercapnia during prenataal development in sheep.

一氧化氮在绵羊产前发育过程中脑血管 NMDA 反应性和高碳酸血症中的作用。

• 发表时间: 2008
• 期刊: Int J Dev Neurosci. 26 (1)
• 作者: Harris AP;Ohata H;Koehler RC.;Ohata H
• 通讯作者: Ohata H

亜鉛化窒素の利点・欠点

锌化氮的优点和缺点

• 发表时间: 2008
• 作者: 大畠博人;長瀬清;土肥修司;大畠博人
• 通讯作者: 大畠博人

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