The effect of gultamate receptor agonist on cerebral microcirculation and to appearance of AQP-4 in perivascular area during various anesthetic state.

[目的]探讨麻醉剂和全麻中使用的药物是否会影响古鲁他明受体激动剂，尤其是AMPA诱导的脑微循环，以及对集中在大鼠脑血管周围星形胶质细胞中的水通道AQP-4的出现的影响。而静脉麻醉药麻醉的AMPA对AQP-4的扩张反应小于吸入麻醉药。我们没有观察到不同麻醉剂对AQP-4的定位差异。本研究结果提示，功能性充血的细胞机制可能受全麻药类型的影响，但在大鼠脑功能充血过程中，胶质细胞的水代谢可能没有变化。

To examine whether anesthetic agents as well as drugs used during general anesthesia could affect cerebral microcirculation induced by gulutamate receptor agonists, especially AMPA, and could affect an appearance of water channel AQP-4 concentrated in astrocyte of perivascular areas in rat brain.AMPA-induced dilation of pial arterioles in rats was observed all anesthetic agents (isoflurane, sevoflurane, propofol, and dexmedetomidine), whereas the dilatory response to AMPA anesthetized with intravenous anesthetics was smaller than that of inhalational anesthetics.We could not observe the differences of localization to AQP-4 among anesthetic agents in rat cortical brain slices superfused with AMPA.The results of this study suggested that cellular mechanisms underlying functional hyperemia might be affected by the type of general anesthetics, however water metabolism in glial cells might be unchanged during functional hyperemia in rat brain.