Limitations of continuous long-term ventilation in the prone position

俯卧位持续长期通气的局限性

• 批准号: 20591830
• 负责人: OKAZAKI Naoto
• 金额: $ 2.41万
• 依托单位: Tottori University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20591830/
• 关键词: 仰臥位; 伏臥位; 人工換気法; 肺酸素化能; 肺傷害; 酸素消費量; ウサギ; 体位; 傷害肺; 腹臥位換気法; サイトカイン

The effects of body position on hemodynamics during hypoxic mechanical ventilation in rabbits in vivo, and on the degree of lung damage caused by hypoxia in vitro (isolated perfused lung) were investigated. Values for heart rates and rate pressure products were high in the prone group, whereas those for cardiac output, oxygen consumption, oxygen delivery and arteriovenous oxygen difference were high in the supine group. The changes in pressure in the prone group and in flow in the supine group were thought to result from a response to hypoxia. The wet to dry weight ratio of the perfused lung was significantly higher, and the capillary filtration coefficient of lung water after hypoxic loading was significantly increased in the prone group. Long-term ventilation in a hypoxic state was apparently problematic for the prone group, as a large volume of blood pooled in the lungs.

本实验观察了体位对在体兔低氧机械通气时血流动力学的影响，以及体位对离体兔低氧肺损伤程度的影响。俯卧位组心率和心率压力乘积值较高，而仰卧位组心输出量、耗氧量、氧输送和动静脉氧差值较高。俯卧组的压力变化和仰卧组的流量变化被认为是对缺氧的反应。俯卧位组灌流肺的湿干重比明显增高，低氧负荷后肺水的毛细血管滤过系数明显增加。在低氧状态下长期通气对俯卧组来说显然是有问题的，因为大量的血液汇集在肺部。