Studies on the long-term effects of general anesthetics on the learning ability of aged rats

全身麻醉药对老年大鼠学习能力的长期影响研究

• 批准号: 20591840
• 负责人: INAGAWA Gaku
• 金额: $ 2.91万
• 依托单位: Yokohama City University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20591840/
• 关键词: 全身麻酔; 認知機能; 概日リズム; 条件付け; 全身麻酔薬; 学習機能; 記憶

It has been reported that isoflurane, an inhalational general anesthetic, impairs spatial learning in rats weeks after the animals wake up from anesthesia. In this study, we tested the hypotheses that (1) isoflurane affects spatial learning after anesthesia in young adult rats, and that (2) this effect is more pronounced if anesthesia is performed during the night time while the rat is more active.The rats were divided into 4 groups (1) isoflurane 1.2% for 2 hours during the day time, (2) no anesthesia but otherwise handled identically as in (1) during the day time, (3) isoflurane 1.2% for 2 hours during the night time, (4) no anesthesia but otherwise handled identically as in (4). The 8-arm radial maze test was started 2 days after anesthesia or handling and continued for 21 days. These 4 groups of rats did not differ in any of the measured paremeters for this test, such as the number of days required to learn the maze. We conclude that isoflurane does NOT affect spatial learning ability after anesthesia in young adult rat, irrespective of whether anesthesia was administered during the day or night.

据报道，异氟烷（一种吸入性全身麻醉剂）会在大鼠从麻醉中醒来数周后损害其空间学习能力。在本研究中，我们验证了以下假设：（1）异氟醚影响年轻成年大鼠麻醉后的空间学习，以及（2）如果在大鼠更活跃的夜间进行麻醉，则这种效果更明显。将大鼠分为4组：（1）白天1.2%异氟醚2小时，（2）不进行麻醉，但在其他方面与（1）中相同地处理，（3）在夜间使用1.2%异氟烷2小时，（4）不进行麻醉，但在其他方面与（4）中相同地处理。在麻醉或处理后2天开始8臂径向迷宫测试，并持续21天。这4组大鼠在本试验的任何测量参数方面均无差异，例如学习迷宫所需的天数。我们的结论是，异氟烷不影响空间学习能力麻醉后，在年轻的成年大鼠，无论是在白天或夜间进行麻醉。

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