Development of anti-TRAIL receptor antibod y in combination with chemotherapeutic therapy against advanced genitourinary cancers : expansion of animal model

开发抗 TRAIL 受体抗体并联合化疗治疗晚期泌尿生殖系统癌症：扩大动物模型

• 批准号: 20591858
• 负责人: WU Xiu-Xian
• 金额: $ 3万
• 依托单位: Kagawa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20591858/
• 关键词: TRAIL-R2; laxatumumab; アドリアマイシン; 腎癌細胞; カスパーゼ; アポトーシス; lexatumumab; Laxatumumab

Development of anti-TRAIL receptor antibody in combination with chemotherapeutic therapy against advanced genitourinary cancers was performed. We found : (1) anti-TRAIL death receptor 2 antibody lexatumumab in combination with clinically achievable concentrations of adriamycin, cisplastin, epirubicin, or pirarubicin had a synergistic cytotoxic effect ; (2) the synergistic cytotoxicity was significantly inhibited by caspase inhibitors demonstrating caspase cascade, especially caspase-8 plays an important role in the synergy ; (3)PCR array analysis identified 26 genes related with apoptosis.

开发抗TRAIL受体抗体并结合化疗治疗晚期泌尿生殖道癌。我们发现：(1)抗TRAIL死亡受体2抗体Lexatumab与临床可达浓度的阿霉素、顺铂、表阿霉素或吡柔比星具有协同细胞毒作用；(2)caspase抑制剂显著抑制协同细胞毒作用，尤其是caspase-8在协同作用中起重要作用；(3)PCR阵列分析发现26个与细胞凋亡相关的基因。

项目成果

分子標的薬を用いた腎細胞がん著効例

分子靶向药物成功治疗肾细胞癌的案例

• 发表时间: 2009
• 期刊: 臨床腫瘍プラクティス 5
• 作者: Essam Elsamman;Ashraf A.Ewis;Nermin Ali;Mohamed D.Saleem;Mohamed Gadelmoula;Yoshinobu Baba;Hiro-omi Kanayama;杉元幹史
• 通讯作者: 杉元幹史

A low molecular weight polysaccharide isolated from Agaricus blazei suppresses tumor growth and angiogenesis in vivo.

• DOI: 10.3892/or_00000201
• 发表时间: 2009
• 期刊: Oncology reports
• 影响因子: 4.2
• 作者: Y. Niu;Jicheng Liu;Xuemei Zhao;X. Wu

hymidylate synthase was associated with patient prognosis and the response to adjuvant therapy in bladder cancer

乙二酸合酶与膀胱癌患者的预后和辅助治疗的反应相关

• 发表时间: 2009
• 期刊: BJU International 103
• 作者: Miyakubo M、Ito K;他;Xiuxian Wu
• 通讯作者: Xiuxian Wu

ヒト固形癌細胞におけるシスプラチンによるカスパーゼ依存性のLexatumumab誘導アポトーシスの増強

Caspase 依赖性增强 Lexatumumab 诱导的人实体瘤细胞凋亡

• 发表时间: 2010
• 作者: 呉秀賢;常森寛行;植月祐次;山下資樹;平間裕美;乾政志;杉元幹史;筧善行
• 通讯作者: 筧善行

Expression of Lysophospholipase D (Autotaxin) and Acylglycerol kinase enzymes in Prostate Cancer cells with relevance to Clinicopathological parameters

溶血磷脂酶 D（自分泌运动因子）和酰基甘油激酶在前列腺癌细胞中的表达与临床病理学参数的相关性

• 发表时间: 2009
• 作者: Matsumoto K;Baba S.;Ito K;Mohammed Ahmed Abdel Muneem Nouh
• 通讯作者: Mohammed Ahmed Abdel Muneem Nouh