Role of bone marrow stromal cells in the bladder with partial outlet obstruction

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Using rats with allogenic bone marrow transplants from transgenic rats expressing green fluorescent protein, we investigated the contributions of bone marrow derived stem cells (BMCs) to the regeneration of the bladder with partial bladder outlet obstruction (PBOO). BMCs were homed into the PBOO bladder, and those cells have potential to differentiate into the bladder tissue components such as the uroepithelium cells, the myofibroblast cells, and smooth muscle cells in the bladder with PBOO.