New therapeutic approach for nasopharyngeal carcinoma using induction of Epstein-Barr virus lytic cycle by anti-cancer chemotherapy

用抗癌药物之一CDDP治疗eb病毒阳性上皮细胞系，可诱导BZLF1蛋白，该蛋白在将EBV潜伏感染转变为裂解周期中起重要作用。未观察到该药明显诱导细胞凋亡。在化疗后鼻咽癌患者的活检标本中，化疗的组织学效应为0级或1级。另一方面，BZLF1的免疫组化无法正常进行。

Treatment of Epstein-Barr virus-positive epithelial cell lines with CDDP, one of anti-cancer drugs, induced BZLF1 protein, which play an important role in switching latent EBV infection to lytic cycle. No clear induction of apoptosis by the drug was observed. In the biopsy specimens taken from post-chemotherapy nasopharyngeal carcinoma patients, histological effect of chemotherapy was grade 0 or 1. On the other hand, immunohistochemistry for BZLF1 could not be properly performed.