Analysis of axonal regeneration of retinal ganglion cells after vascularized peripheral nerve graft.

视网膜神经节细胞属于中枢神经系统，一旦轴突被切断，就不能自发再生轴突。当自体周围神经移植到视神经残端时，只有少数视网膜神经节细胞能再生轴突。在这项研究中，我们试图移植带血管的周围神经，结果表明，与未移植血管的周围神经相比，移植的视网膜神经节细胞有大量的轴突再生。我们的结果表明，带血管的周围神经移植促进了视网膜神经节细胞的轴突再生。

Retinal ganglion cells belong to the central nervous systems and once their axons are transected, they cannot regenerate their axons spontaneously. When autologous peripheral nerve is grafted to the optic nerve stump, only small populations of retinal ganglion cells regenerate their axons. In this study, we tried to graft vascularized peripheral nerve and showed that large number of retinal ganglion cells regenerated their axons into the graft than that without vascularization. Our results suggest that vascularized peripheral nerve graft promotes axonal regeneration of retinal ganglion cells.