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Early in vivo Evaluation of Ventricular Assistance with a Miniature Centrifugal Blood Pump (TinyPump) in Rabbits

兔微型离心血泵 (TinyPump) 心室辅助的早期体内评价

基本信息

批准号：
20592090
负责人：
SHIOKAWA Yuichi
金额：
$ 2.91万
依托单位：
Kyushu University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2008
资助国家：
日本
起止时间：
2008 至 2010
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20592090/
关键词：
小児体外循環小型遠心ポンプ左心補助

项目摘要

We have developed an ultraminiature centrifugal pump, TinyPunip, with a priming volume of 5 ml. The in vivo performance of Tiny Pump was compared with that of HPM-05 for left ventricular support. Each pump group included 7 rabbits weighing 3.4-3.8kg. One rabbit in the TinyPump group and two rabbits in the HPM-05 goup died of unsuccessful cannulation. The remaining rabbits (6 in the TinyPump group and 5 in the HPM-05 group) were instrumented and observed for 240 min. The pump flow was maintained at around 200 ml/min. The priming volumes of the entire circuits were 25 and 45ml for TinvPump and HPM-05, respectly. TinyPump required a higher rotation speed (2214±47 vs.1261±87 rpm, p<0.05)because of its Km all priming Volume, but showed a similar plasma free hemoglobin level to HPM-05. The hematocrit values were kept higher in the TinyPump group during ventricular support (24.3±1.4% vs. 20.1±1.4% at 240 min, p<0.05),The mean arterial pressure did not differ between the two groups. The biochemical parameters were also equivalent in the two groups. Overall, TinyPump exhibited a feasible in vivo performance. This ultraminiature device would offer promising outcomes for neonates and infants with intractable heart failure.

我们已经开发出一种超小型离心泵，TinyPunip，预充量为5 ml。比较了微型泵和HPM-05在左心室支持方面的体内性能。每组包括7只体重3.4-3.8kg的家兔。TinyPump组和HPM-05组分别有1只和2只家兔死于插管失败。剩余家兔（TinyPump组6只，HPM-05组5只）进行器械化观察240 min，泵流量维持在200 ml/min左右，TinvPump和HPM-05的整个管路预充量分别为25和45 ml。TinyPump需要更高的转速（2214±47 vs. 1261 ±87 rpm，p<0.05），因为其Km全预充体积，但显示出与HPM-05相似的血浆游离血红蛋白水平。在心室支持期间，TinyPump组的红细胞压积值保持较高（240分钟时为24.3±1.4% vs. 20.1±1.4%，p<0.05），两组之间的平均动脉压无差异。两组的生化指标也相当。总体而言，TinyPump表现出可行的体内性能。这种超微型设备将为患有顽固性心力衰竭的新生儿和婴儿提供有希望的结果。