Early in vivo Evaluation of Ventricular Assistance with a Miniature Centrifugal Blood Pump (TinyPump) in Rabbits

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We have developed an ultraminiature centrifugal pump, TinyPunip, with a priming volume of 5 ml. The in vivo performance of Tiny Pump was compared with that of HPM-05 for left ventricular support. Each pump group included 7 rabbits weighing 3.4-3.8kg. One rabbit in the TinyPump group and two rabbits in the HPM-05 goup died of unsuccessful cannulation. The remaining rabbits (6 in the TinyPump group and 5 in the HPM-05 group) were instrumented and observed for 240 min. The pump flow was maintained at around 200 ml/min. The priming volumes of the entire circuits were 25 and 45ml for TinvPump and HPM-05, respectly. TinyPump required a higher rotation speed (2214±47 vs.1261±87 rpm, p<0.05)because of its Km all priming Volume, but showed a similar plasma free hemoglobin level to HPM-05. The hematocrit values were kept higher in the TinyPump group during ventricular support (24.3±1.4% vs. 20.1±1.4% at 240 min, p<0.05),The mean arterial pressure did not differ between the two groups. The biochemical parameters were also equivalent in the two groups. Overall, TinyPump exhibited a feasible in vivo performance. This ultraminiature device would offer promising outcomes for neonates and infants with intractable heart failure.