Clarification of the three-dimensional structure of vascular malformations by objective differentiation between blood vessels and lymphatic vessels, and its clinical application

使用我们最近开发的包括LYVE-1抗体在内的邦蒂富尔丰富的血管内皮细胞免疫组织化学标记物对血管畸形的病变血管进行免疫组织化学检查。这项研究表明，各种模式的免疫组织化学标记物表达的血管畸形，可以归类为同一类别的血管畸形，如淋巴管畸形或静脉畸形。这表明它们遵循不同的发病机制。此外，免疫组织化学方法使得更容易正确诊断各种微血管的病理。它已被证明，这种方法是有用的，以准确诊断的微小浸润到小淋巴管在早期阶段的胃肠癌，并在确定适当的管理冠状动脉疾病。

Immunohistochemical examinations were performed on the morbid vessels of vascular malformations using bountiful immunohistochemical markers of vascular endothelial cells including LYVE-1 antibodies, which we had recently developed. This study demonstrated that various patterns of immunohistochemical markers were expressed in vascular malformations which could be classified in the same category of vascular malformations such as either lymphatic vessel malformations or venous malformations. This suggests that they follow a different pathogenesis. In addition, the immunohistochemical method has made it easier to properly diagnosis the pathology of various microvessels. It has been demonstrated that this method is useful for accurate diagnosis of microinvasion into the small lymph vessels during the early stages of gastroenterological carcinoma and in determining the proper management of coronary disorders.