Therapeutic strategies against bone resorption using calcineurin signaling in osteoclast

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Small molecular compounds that potently affect osteoclastogenesis could be useful as a chemical probe for elucidating the mechanism of biological phenomena and form the basis for effective therapeutic strategies against bone resorption. To establish a high-throughput screening system for identifying osteoclastogenesis-related compounds using a cell-based sensor, and to identify novel chemical entities regulating signaling pathways in osteoclasts. Harmine activates NFATc1 expression independent of RANKL stimulation, as well as enhanced Id2 expression in osteoclast precursor cells. These multimodal actions of harmine may overall suppress osteoclastogenesis.