Involvement of obesity in oral carcinogenesis using animal models

使用动物模型研究肥胖与口腔癌发生的关系

• 批准号: 20592209
• 负责人: TANAKA Takuji
• 金额: $ 3.08万
• 依托单位: Kanazawa Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20592209/
• 关键词: 実験腫瘍学; 肥満; 舌がん; 発がん感受性; 前炎症性サイトカイン; db/dbマウス; 舌発がん; db; dbマウス; ob; obマウス; 癌; 細胞・組織; 動物; 口腔

We investigated whether obesity influences oral (tongue) carcinogenesis using obese model animals, such as db/db and ob/ob mice. The results indicated that the obese mice were highly susceptible to 4-NQO-induced tongue and esophageal carcinogenesis when compared to their wild types (WT) of mice. In addition, the susceptibility was high in db/db mice in comparison with ob/ob mice. The immunohistochemical expression of pro-inflammatory cytokines (IL-1α, IL-1β, interleukin-4, interleukin-6, interleukin-8, and TNF-α) in the tongue squamous cell carcinomas which developed in the db/db mice were significantly greater than that developed in the WT mice (p<0.05-p<0.01). However, there were no significant differences in the expressions of NF-κB, Stat3, and Nrf2 between the obese and WT mice. Our results may suggest that overexpression of these pro-inflammatory cytokines plays an important role in highly susceptible to 4-NQO-induced tongue and esophageal carcinogenesis in obese mice.

我们使用肥胖模型动物，如db/db和ob/ob小鼠，研究肥胖是否影响口腔（舌）癌变。结果表明，与野生型小鼠相比，肥胖小鼠对4-NQO诱导的舌和食管癌发生高度敏感。此外，与ob/ob小鼠相比，db/db小鼠的易感性较高。db/db小鼠舌鳞癌中促炎细胞因子（IL-1α、IL-1β、IL-4、IL-6、IL-8和TNF-α）的免疫组化表达显著高于WT小鼠（p<0.05-p<0.01）。然而，NF-κB、Stat 3和Nrf 2在肥胖小鼠和WT小鼠之间的表达无显著差异。我们的研究结果可能表明，这些促炎细胞因子的过度表达在肥胖小鼠对4-NQO诱导的舌和食管癌的高度易感性中起着重要作用。

项目成果

Colorectal carcinogenesis and suppression of tumor development by inhibition of enzymes and molecular targets.

通过抑制酶和分子靶标来预防结直肠癌发生和抑制肿瘤发展。

• 发表时间: 2009
• 期刊: Curr.Enzyme Inhibition 5
• 作者: Yasui Y;Kim M;Oyama T;Tanaka T
• 通讯作者: Tanaka T

Suppressive effects of nobiletin on hyperleptinemia and colitis-ralted colon carcinogenesis in male ICR mice.

川陈皮素对雄性 ICR 小鼠高瘦素血症和结肠炎相关结肠癌的抑制作用。

• 发表时间: 2008
• 期刊: Carcinogenesis 29
• 作者: Miyamoto S;Yasui Y;Tanaka T;Ohigashi H;Murakami A
• 通讯作者: Murakami A

米ぬか由来トリシンの発がん予防作用とそのメカニズム

米糠曲霉素的致癌作用及机制

• 发表时间: 2010
• 作者: Tanaka T;Yasui Y;Terasaki M;Masuda S;Takuji Tanaka;Takuji Tanaka;Takuji Tanaka;田中卓二
• 通讯作者: 田中卓二

Melatonin suppresses AOM/DSS-induced large bowel oncogenesis in rats.

• DOI: 10.1016/j.cbi.2008.10.047
• 发表时间: 2009-01
• 期刊: Chemico-biological interactions
• 影响因子: 5.1
• 作者: Takuji Tanaka;Y. Yasui;Mayu Tanaka;Takahiro Tanaka;T. Oyama;KM Wahidur Rahman

Enhanced colitis-associated colon carcinogenesis in a novel Apc mutant rat

• DOI: 10.1111/j.1349-7006.2009.01287.x
• 发表时间: 2009-11-01
• 期刊: CANCER SCIENCE
• 影响因子: 5.7
• 作者: Yoshimi, Kazuto;Tanaka, Takuji;Kuramoto, Takashi
• 通讯作者: Kuramoto, Takashi