Functional analysis of periostin -anti-apoptotic action of periostin in osteoblasts and periodontal ligament cells

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In this study, we examined the effect of periostin on the function of osteoblasts and periodontal ligament cells, such as apoptosis and the associated signal pathway. In the result, it is revealed that periostin is associated with the apoptosis of periodontal ligament cells by the hypoxia-induced system, and the signaling pathway including FAK, JNK, ERK, P38 and AKT. Additionally, in the signaling pathway of β-catenin, periostin might affect the anti-apoptotic action in various cells.