Investigation of the mechanisms of osteogenic differentiation by RhoA in periodontal ligament cells for cell transplantation
Investigation of the mechanisms of osteogenic differentiation by RhoA in periodontal ligament cells for cell transplantation
批准号:
20592429
负责人:
YAMAMOTO Tadashi
金额:
$2.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
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英文摘要
In periodontal ligament cells (PDL cells), cytoskeletal signaling regulated by Rho-ROCK is critical in the differentiation process, and the expression of osteogenic genes such as BMP-4, Wnt3a, and Wnt5a. Meanwhile over-expression of RhoA or ROCK showed significant low cell proliferation, suggesting that PDL cells differentiation is coordinately regulated by Rho-ROCK induced cytoskeletal molecules, as well as soluble growth factors and extracellular matrix.
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Rho kinasesによる?歯根膜細胞の分化制御
Rho 激酶对牙周膜细胞分化的调节
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[鵜川祐樹, 山本直史, Yamamoto T, 山本直史, 山本直史]
通讯作者:
山本直史
歯根膜細胞の分化過程におけるBMPとWntシグナルへのRho kinasesの影響
Rho激酶对牙周膜细胞分化过程中BMP和Wnt信号的影响
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[鵜川祐樹]
通讯作者:
鵜川祐樹
Rho kinasesによる歯根膜細胞の分化制御
Rho 激酶对牙周膜细胞分化的调节
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[鵜川祐樹, 山本直史, Yamamoto T, 山本直史]
通讯作者:
山本直史
DOI:
10.1016/j.diff.2014.09.002
发表时间:
2014-09
期刊:
Differentiation; research in biological diversity
影响因子:
--
作者:
[Tadashi Yamamoto;Yuki Ugawa;K. Yamashiro;M. Shimoe;Kazuya Tomikawa;S. Hongo;Shinsuke Kochi;Hidetaka Ideguchi;H. Maeda;S. Takashiba]
通讯作者:
Tadashi Yamamoto;Yuki Ugawa;K. Yamashiro;M. Shimoe;Kazuya Tomikawa;S. Hongo;Shinsuke Kochi;Hidetaka Ideguchi;H. Maeda;S. Takashiba
Cell cycle atlas of periodontium
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批准号:23659977
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.25万
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负责人:YAMAMOTO Tadashi
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依托单位:
Analysis of pathogenesis and pathophysiology of chronic kidney disease glomerulus by microproteomics
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批准号:21390262
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$10.9万
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负责人:YAMAMOTO Tadashi
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Comprehensive Research on Empire and Commonwealth: Focusing on Their Roles in the Formation of Contemporary International Orders
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批准号:21320143
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.4万
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财政年份:2009
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Regulation and de-regulation of NMDA receptor-dependent synaptic plasticity through its tyrosine phosphorylation
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批准号:19390070
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$12.06万
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财政年份:2007
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负责人:YAMAMOTO Tadashi
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依托单位:
Regulatory roles of protein phosphorylation in cell growth and malignant transformation
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批准号:17013021
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项目类别:Grant-in-Aid for Scientific Research on Priority Areas
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资助金额:$94.4万
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财政年份:2005
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负责人:YAMAMOTO Tadashi
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依托单位:
Microtranscriptomics and microproteomics of human glomerular diseas
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批准号:17390247
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$10.37万
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财政年份:2005
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负责人:YAMAMOTO Tadashi
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依托单位:
Genomics and Proteomics for Pathogensis and Pathophysiology of IgA Nephropathy
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批准号:13470209
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.45万
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财政年份:2001
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负责人:YAMAMOTO Tadashi
-
依托单位:
Mechanisms of cell growth and malignant transformation regulated by protein phosphorylation and dephosphorylation
-
批准号:12219201
-
项目类别:Grant-in-Aid for Scientific Research on Priority Areas
-
资助金额:$149.57万
-
财政年份:2000
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负责人:YAMAMOTO Tadashi
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依托单位:
Roles of Tyrosine Phosphorylation in The Development and Plasticity of The Central Nervous System
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批准号:11308031
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$24.9万
-
财政年份:1999
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负责人:YAMAMOTO Tadashi
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依托单位:
A study on world complex societies and constructing social information systems
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批准号:10610312
-
项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.66万
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财政年份:1998
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负责人:YAMAMOTO Tadashi
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依托单位:
Cloning and Functional Analysis of Genes Governing Characteristics of Renal Glomerulus
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批准号:09470237
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$5.57万
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财政年份:1997
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负责人:YAMAMOTO Tadashi
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依托单位:
Mechanism of Glomerular Injury Mediated by CD8^+ Lymphocytes in Anti-GBM Nephritis of WKY Rats
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批准号:06670216
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项目类别:Grant-in-Aid for General Scientific Research (C)
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财政年份:1994
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依托单位:
Information Exchange on Cancer Research with North American
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负责人:YAMAMOTO Tadashi
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依托单位:
Atrial Natriuretic Peptide Receptors on the Glomerular Epithelial Cell and Their Roles in Regulation of Glomerular Ultrafiltration
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批准号:03807018
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$0.45万
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财政年份:1991
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负责人:YAMAMOTO Tadashi
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依托单位:
Regulation of Glomerular Ultrafiltration by Glomerular Epithelial Cells
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批准号:02044057
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项目类别:Grant-in-Aid for international Scientific Research
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资助金额:$5.63万
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财政年份:1990
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负责人:YAMAMOTO Tadashi
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依托单位:
Growth Factor for Mesangial Cell : Tumor Necrosis Factor and Interleukin 1
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批准号:01570189
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资助金额:$1.41万
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负责人:YAMAMOTO Tadashi
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依托单位:
海外基金