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Investigation of the mechanisms of osteogenic differentiation by RhoA in periodontal ligament cells for cell transplantation

Investigation of the mechanisms of osteogenic differentiation by RhoA in periodontal ligament cells for cell transplantation
用于细胞移植的牙周膜细胞中RhoA成骨分化机制的研究
批准号:
20592429
负责人:
YAMAMOTO Tadashi
金额:
$2.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010

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中文摘要
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英文摘要
In periodontal ligament cells (PDL cells), cytoskeletal signaling regulated by Rho-ROCK is critical in the differentiation process, and the expression of osteogenic genes such as BMP-4, Wnt3a, and Wnt5a. Meanwhile over-expression of RhoA or ROCK showed significant low cell proliferation, suggesting that PDL cells differentiation is coordinately regulated by Rho-ROCK induced cytoskeletal molecules, as well as soluble growth factors and extracellular matrix.
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会议论文
Rho kinasesによる?歯根膜細胞の分化制御
Rho 激酶对牙周膜细胞分化的调节
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [鵜川祐樹, 山本直史, Yamamoto T, 山本直史, 山本直史]
通讯作者: 山本直史
歯根膜細胞の分化過程におけるBMPとWntシグナルへのRho kinasesの影響
Rho激酶对牙周膜细胞分化过程中BMP和Wnt信号的影响
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [鵜川祐樹]
通讯作者: 鵜川祐樹
Rho kinasesによる歯根膜細胞の分化制御
Rho 激酶对牙周膜细胞分化的调节
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [鵜川祐樹, 山本直史, Yamamoto T, 山本直史]
通讯作者: 山本直史
DOI: 10.1016/j.diff.2014.09.002
发表时间: 2014-09
期刊: Differentiation; research in biological diversity
影响因子: --
作者: [Tadashi Yamamoto;Yuki Ugawa;K. Yamashiro;M. Shimoe;Kazuya Tomikawa;S. Hongo;Shinsuke Kochi;Hidetaka Ideguchi;H. Maeda;S. Takashiba]
通讯作者: Tadashi Yamamoto;Yuki Ugawa;K. Yamashiro;M. Shimoe;Kazuya Tomikawa;S. Hongo;Shinsuke Kochi;Hidetaka Ideguchi;H. Maeda;S. Takashiba
Cell cycle atlas of periodontium
  • 批准号:
    23659977
  • 项目类别:
    Grant-in-Aid for Challenging Exploratory Research
  • 资助金额:
    $2.25万
  • 财政年份:
    2011
  • 负责人:
    YAMAMOTO Tadashi
  • 依托单位:
Analysis of pathogenesis and pathophysiology of chronic kidney disease glomerulus by microproteomics
  • 批准号:
    21390262
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
  • 资助金额:
    $10.9万
  • 财政年份:
    2009
  • 负责人:
    YAMAMOTO Tadashi
  • 依托单位:
Comprehensive Research on Empire and Commonwealth: Focusing on Their Roles in the Formation of Contemporary International Orders
  • 批准号:
    21320143
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
  • 资助金额:
    $11.4万
  • 财政年份:
    2009
  • 负责人:
    YAMAMOTO Tadashi
  • 依托单位:
Regulation and de-regulation of NMDA receptor-dependent synaptic plasticity through its tyrosine phosphorylation
  • 批准号:
    19390070
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
  • 资助金额:
    $12.06万
  • 财政年份:
    2007
  • 负责人:
    YAMAMOTO Tadashi
  • 依托单位:
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