Regulation of the Spontaneous Augmentation of NaV1.9 in Mouse Dorsal Root Ganglion Neurons.

NaV1.9自发增强的机制尚不清楚。我们研究了蛋白激酶A和C(PKA和PKC)在NAV1.9自发增强中的作用。激活PKA可显著抑制NAV1.9电流的自发增强，而激活PKA不影响NAV1.9电流失活的电压依赖性。这些结果表明，NAV1.9的自发增强是由PKA直接调节的，而PKC是间接调节的。

The mechanism underlying the spontaneous augmentation of NaV1.9is still unclear. We examined the effects of protein kinases A and C (PKA and PKC), on the spontaneous augmentation of NaV1.9. The spontaneous augmentation of the NaV1.9 current was significantly suppressed by activation of PKA, whereas activation of PKA did not affect the voltage dependence of inactivation for the NaV1.9 current. These results indicate that the spontaneous augmentation of NaV1.9 was regulated directly by PKA, and indirectly by PKC.