Involvement of the gasotransmitter hydrogen sulfide in neurogenic pain
Involvement of the gasotransmitter hydrogen sulfide in neurogenic pain
批准号:
20602016
负责人:
KAWABATA Atsufumi
金额:
$2.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
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英文摘要
We first demonstrated the involvement of Cav3.2 T-type calcium channels in hydrogen sulfide-induced facilitation of nociception. We then found that, in rats with L5 spinal nerve injury, the activation of Cav3.2 by endogenous hydrogen sulfide was involved in the maintenance of hyperalgesia/allodynia, and Cav3.2 was upregulated, suggesting that the hydrogen sulfide/Cav3.2 pathway should be a therapeutic target for treatment of neurogenic pain.
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気体メディエーターとしての硫化水素の神経機能
硫化氢作为气体介质的神经功能
DOI:
--
发表时间:
2009
期刊:
脳21 12巻
影响因子:
--
作者:
[Maeda Y., Aoki Y., Sekiguchi F., Matsunami M., Takahashi T., Nishikawa H., Kawabata A., 川畑篤史]
通讯作者:
川畑篤史
皮膚透過性新規アスコルビン酸プロドラッグ disodium isostearyl 2-0-1-ascorbyl phosphate 軟膏の神経障害性疼痛治療への応用
透皮型新型抗坏血酸前药异硬脂酰2-0-1-抗坏血酸磷酸酯二钠软膏在神经病理性疼痛治疗中的应用
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[大久保寿政, 川畑篤史, 他]
通讯作者:
他
Roles of hydrogen sulfide in processing of inflammatory pain. In a symposium, "Hydrogen sulfide in inflammation"
硫化氢在炎性疼痛处理中的作用。
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Aoki Y., Maeda Y., Matsunami, M., Kawabata A., 川畑篤史]
通讯作者:
川畑篤史
Roles of hydrogen sulfide and T-type calcium channels in chemotherapy-evoked neuropathic hyperalgesia in rats.
硫化氢和 T 型钙通道在化疗引起的大鼠神经性痛觉过敏中的作用。
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Okubo K., Matsunami M., Takahashi T., Kawabata A.]
通讯作者:
Kawabata A.
Peripheral hydrogen sulfide induces hypersensitivity to C-fiber-preferential sine-wave stimulation and concomitant potentiation of ERK phosphorylation in the spinal dorsal horn neurons
外周硫化氢诱导对 C 纤维优先正弦波刺激的超敏反应,并伴随脊髓背角神经元中 ERK 磷酸化的增强
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Aoki Y., Maeda Y., Matsunami, M., Kawabata A.]
通讯作者:
Kawabata A.
共 27 条
Prevention and treatment of chemotherapy-induced neuropathic pain and visceral pain by targeting HMBG1, a nuclear protein
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批准号:26460710
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.24万
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财政年份:2014
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负责人:KAWABATA Atsufumi
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依托单位:
Pain regulation by PKA and calcineurin through functional modulation of T-type calcium channels
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批准号:23590729
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项目类别:Grant-in-Aid for Scientific Research (C)
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财政年份:2011
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负责人:KAWABATA Atsufumi
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依托单位:
Study on roles for PAR-2, a G protein-coupled receptor, in acute inflammation
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批准号:13672405
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.18万
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财政年份:2001
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负责人:KAWABATA Atsufumi
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依托单位:
ROLES OF PROTEASE-ACTIVATED RECEPTORS IN THE ALIMENTARY SYSTEMS : PARTICIPATION IN THE MODULATION OF FUNCTIONS IN THE SALIVARY GLANDS, PANCREAS AND SMALL INTESTINE
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批准号:11672283
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.34万
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财政年份:1999
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负责人:KAWABATA Atsufumi
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依托单位:
海外基金