Research of inhibitors for nuclear transport or enzyme activity of protein kinases encoded by human herpesviruses

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Human herpesvirus 6 (HHV-6) ganciclovir-resistant strain was obtained with amino acid substitutions associated with the death of a recipient after an allogeneic stem cell transplant recipient. The substitutions on U38 DNA polymerase of HHV-6 were associated with the ganciclovir-resistance of HHV-6. The assays to detect antiviral drug-resistance mutations of HHV-6 were developed. The assay has been developing the powerful detection system which is rapid and multi-screening method. The nuclear transport mechanism of U69 protein was cleared, and it is started that the multi-screening assay system is been developing to detect the inhibitors for the nuclear transport.