Structure determination method for non-crystallizable proteins by synchrotron radiation hard X-rays
Structure determination method for non-crystallizable proteins by synchrotron radiation hard X-rays
批准号:
20612022
负责人:
IWAMOTO Hiroyuki
金额:
$2.91万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
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英文摘要
About 70% of currently used medical drugs are said to be targeted to membrane proteins. Because of this, the knowledge about the 3D structure of these proteins is indispensable for the development of new drugs. However, the structures of only a few of the membrane proteins have been solved, because it is generally difficult to obtain crystals of these proteins, which are indispensable for the standard procedure of structure determination. This study is conducted to develop the principles needed to determine the structure of these proteins without making crystals, by applying the technique of X-ray holography.
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Hard X-ray Fourier transform holography from an array of oriented, referenced objects.
来自一系列定向参考物体的硬 X 射线傅立叶变换全息术。
DOI:
--
发表时间:
2011
期刊:
J.Synchrotron Rad. 18
影响因子:
--
作者:
[Iwamoto, H., Yagi, N.]
通讯作者:
N.
Hard X-ray Fourier transform holography from an array of oriented, referenced objects
来自一系列定向参考物体的硬 X 射线傅里叶变换全息术
DOI:
--
发表时间:
2011
期刊:
Journal of Synchrotron Radiation
影响因子:
2.5
作者:
[Iwamoto, H., Yagi, N.]
通讯作者:
N.
Study on the mechanism of action of insect flight muscle using muscle fibers with exchanged protein components
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财政年份:2014
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负责人:IWAMOTO Hiroyuki
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依托单位:
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负责人:IWAMOTO Hiroyuki
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依托单位: