Establishment of autoimmune disease therapies based on the elucidation of target genes

基于靶基因的阐明建立自身免疫性疾病治疗方法

• 批准号: 20679005
• 负责人: YASUTOMO Koji
• 金额: $ 67.56万
• 依托单位: The University of Tokushima
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (S)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20679005/
• 关键词: 自己免疫疾患; T細胞; ゲノム解析; Notch; 自己免疫; Tリンパ球; 転写調節; 細胞治療; 分子標的治療

We aim to reveal the molecular mechanisms to maintain immune homeostasis in order to establish therapeutic strategies for human immune-mediated disorders. We demonstrated the crucial roles of Notch signaling in cytotoxic T cellsresponses, IL-22 production from CD4+ T cells, the differentiation of macrophages in the small intestine and maintenance of memory T cells. Furthermore, we identified PSMB8 as a causative gene for a new type of autoinflammatory syndrome.

我们的目标是揭示维持免疫稳态的分子机制，以便为人类免疫介导的疾病建立治疗策略。我们证明了 Notch 信号传导在细胞毒性 T 细胞反应、CD4+ T 细胞产生 IL-22、小肠巨​​噬细胞分化和记忆 T 细胞维持中的关键作用。此外，我们确定 PSMB8 是一种新型自身炎症综合征的致病基因。

项目成果

Jagged1 Suppresses Collagen-Induced Arthritis by Indirectly Providing a Negative Signal in CD8+ T Cells

• DOI: 10.4049/jimmunol.0803765
• 发表时间: 2009-03-15
• 期刊: JOURNAL OF IMMUNOLOGY
• 影响因子: 4.4
• 作者: Kijima, Mika;Iwata, Akiko;Yasutomo, Koji
• 通讯作者: Yasutomo, Koji

Notch provides metabolic signals in memory CD4+ T cells

Notch 在记忆 CD4 T 细胞中提供代谢信号

• 发表时间: 2012
• 作者: ○須田健資;平野正雄;田中 健;Hirofumi Shimizu;Kenji Miyao;Koji Yasutomo
• 通讯作者: Koji Yasutomo

Coordinated regulation of transcription factors through Notch2 is an important mediator of mast cell fate

• DOI: 10.1073/pnas.0801074105
• 发表时间: 2008-06-03
• 期刊: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• 影响因子: 11.1
• 作者: Sakata-Yanagimoto, Mamiko;Nakagami-Yamaguchi, Etsuko;Chiba, Shigeru
• 通讯作者: Chiba, Shigeru

Notch controls T cell effector functions

Notch 控制 T 细胞效应功能

• 发表时间: 2008
• 作者: (INVITED) Tsuyoshi Sekitani;Takao Someya;前川洋一
• 通讯作者: 前川洋一

Notch signaling drives IL-22 secretion in CD4+ T cells by stimulating the aryl hydrocarbon receptor

• DOI: 10.1073/pnas.0911755107
• 发表时间: 2010-03-30
• 期刊: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• 影响因子: 11.1
• 作者: Alam, Muhammad Shamsul;Maekawa, Yoichi;Yasutomo, Koji
• 通讯作者: Yasutomo, Koji