Establishment of autoimmune disease therapies based on the elucidation of target genes

我们的目的是揭示维持免疫稳态的分子机制，以便建立人类免疫介导疾病的治疗策略。我们证明了Notch信号在细胞毒性T细胞应答、CD4+ T细胞产生IL-22、小肠巨噬细胞分化和记忆T细胞维持中的关键作用。此外，我们发现PSMB8是一种新型自身炎症综合征的致病基因。

We aim to reveal the molecular mechanisms to maintain immune homeostasis in order to establish therapeutic strategies for human immune-mediated disorders. We demonstrated the crucial roles of Notch signaling in cytotoxic T cellsresponses, IL-22 production from CD4+ T cells, the differentiation of macrophages in the small intestine and maintenance of memory T cells. Furthermore, we identified PSMB8 as a causative gene for a new type of autoinflammatory syndrome.