Creation of the 2nd generation peptide aptamer which dynamically controls interface between biomolecule and inorganic surface.

本研究旨在创造一种生物分子元件，实现人工肽与无机材料结合和解结合的动态控制。利用组合工程技术成功构建了含Zn-finger基序框架的噬菌体文库，用于筛选第二代肽适配体。我还成功地分析了肽适体与无机表面之间的详细界面结构。在此结构基础上，进行了人工肽和人工蛋白的设计合成。

The present study aims at the creation of a biomolecular element that achieves the dynamic control of binding and the unbinding between an artificial peptide and an inorganic material. I succeeded in making the phage library where the Zn-finger motif frame to screen by combinatorial engineering for the 2nd generation peptide aptamer. I also successfully analyzed in a detailed interfacial structure between a peptide aptamer and inorganic surface. Based on this structure, the design synthesis of the artificial peptide and the artificial protein was carried out.