Biological effects of hydroxylated PCBs on Japanese flounder

本研究利用牙鲆胚胎研究了多氯联苯代谢物羟基化多氯联苯（OH-PCBs）的早期毒性。暴露试验表明，4-羟基-2′，3,5,5′-四氯联苯超过1 ppb可引起比目鱼头部周围神经系统畸形。本研究表明，oh -多氯联苯可在体内和体外破坏甲状腺激素功能。

In the present study, we investigated the early life stage toxicity of hydroxylated polychlorinated biphenyls (OH-PCBs), metabolites of PCBs, using Japanese flounder embryos. The exposure test revealed that more than 1 ppb of an isomer of OH-PCBs, 4-hydroxy-2',3,5,5'-tetrachlorobiphenyl, caused malformation of peripheral nervous system in head part of flounders. The present study suggests that OH-PCBs could disrupt thyroid hormone functions in vivo as well as in vitro.