Biological effects of hydroxylated PCBs on Japanese flounder

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In the present study, we investigated the early life stage toxicity of hydroxylated polychlorinated biphenyls (OH-PCBs), metabolites of PCBs, using Japanese flounder embryos. The exposure test revealed that more than 1 ppb of an isomer of OH-PCBs, 4-hydroxy-2',3,5,5'-tetrachlorobiphenyl, caused malformation of peripheral nervous system in head part of flounders. The present study suggests that OH-PCBs could disrupt thyroid hormone functions in vivo as well as in vitro.