Selective synthesis of luminescent metal nanoclusters for intracellular imaging

合成了一种具有两个同向二硫键的新型卟啉类钝化剂。当金(III)离子在钝化剂存在下被还原时，很容易得到较小的金纳米团簇。由于卟啉分子的存在，生成的金纳米团簇显示出强烈的荧光。用含锰的卟啉钝化剂制备的金纳米粒子加速了水质子的弛豫，表明该纳米粒子可以作为磁共振造影剂。

A new porphyrin-based passivant was synthesized which has two disulfide bonds in the same direction. Small gold nanoclusters were easily obtained when gold(III) ion was reduced in the presence of the passivants. Resulting gold nanoclusters exhibited an intense fluorescence due to the porphyrin molecules. Gold nanoparticles prepared with manganese-inserted porphyrin passivants accelerated the relaxation of water protons, indicating that the nanoparticles could be used as a MRI contrast agent.