Development of molecular target peptide screening system by using a highly effective protein immobilization

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We have examined a novel peptide drug screening system by which the affinity peptides that bind to functional domain of FoxP3 (target protein) could be effectively obtained by applying highly functional protein immobilization method developed in our group. As the results, functional immobilization of trimmed FoxP3 was verified at first. In addition, several affinity peptides that could significantly inhibit the binding of relevant oligo DNA to functional domain of FoxP3 were successfully isolated from T7 phage random peptide library.