Study on crystallization and polymorphism of amyloidgenic proteins on biomembranes

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Amyloid firbril formation is similar to a crystallization. The amyloid fibrils fragmented in advance has been reported to play a role for a seeds. The seeds showed the variety of their growth behavior in the presence of the model biomembranes (liposomes). The addition of oxidative stress could lead to the formation of radiated amyloid fibrils (spherulite) and as well as the oxidized liposome could. It is, therefore, suggested that the liposome membranes determined the polymorphism of the amyloid.