Neural basis of anxiety and onset of panic disorder.

本研究旨在阐明惊恐障碍的发病机制。本研究探讨了健康成人在情绪记忆任务中的主观焦虑与皮肤电传导率监测的自主神经反应之间的关系。我们还调查了惊恐障碍患者在首次就诊时首次惊恐发作的位置和3年结局的临床特征。我们的研究结果表明，高焦虑特质可能会影响健康成人的自主活动的不稳定性的记忆回忆。在对惊恐障碍患者的研究中，结果显示惊恐障碍患者根据其首次惊恐发作的部位具有不同的临床特征。

The present study aimed to clarify the onset mechanism of panic disorder. We examined the relationship between the subjective anxiety and the autonomic responses monitored by the skin conductance rate during the emotional memory task in healthy adults. We also investigated the clinical features of panic disorder patients with respect to the place of their first panic attack at the first visit and in the 3-year outcome. Our results suggest that high-anxiety traits may influence the memory recall by the instability of autonomic activity in healthy adults. In the research of patients with panic disorder, the results showed that panic disorder patients have differential clinical features according to the place of their first panic attack.