Combination-oriented molecular-targeting prevention of cancer : targeting TRAIL and microRNA.

miR-221/222有助于抵抗TRAIL。我构建了质粒来评估miR-221/222的启动子激活水平，以筛选具有miR-221/222抑制因子活性的食品成分。我发现PUMA是miR-221/222新的靶基因。TRAIL耐药机制及其与miR-221/222的关联可能得到证实。作为trail致敏化合物，我们新发现了6种材料。此外，作为提高TRAIL表达水平的成分，我们报道了乳酸菌。

miR-221/222 contributes to TRAIL resistance. I built plasmid to evaluate a promoter activation level of miR-221/222 for the screening of the food composition with the repressor activity of miR-221/222.I found that PUMA was a new target gene of miR-221/222. TRAIL resistance mechanism and association with miR-221/222 might be proved.As a TRAIL-sensitizing compounds, we found six kinds of materials newly. Furthermore, as the ingredient which enhanced TRAIL expression level, we reported lactic acid bacterium.