Development of prophylactic therapy against sepsis and hepatic failure in rat short bowel models managed with total parenteral nutrition

点击翻译按钮获取中文摘要

The rat short bowel model was established by massive intestinal resection. The animals were managed with total parenteral nutrition and were investigated whether administration of neuropeptide, bombesin, had favorable effect against cholestatic liver dysfunction induced by total parenteral nutrition. During this investigation, technical difficulty was encountered for the maintenance of long-term total parenteral nutrition.As a result, bombesin could suppress bacterial translocation from intestinal mucosa and ameliorate the extent of cholestatic liver dysfunction.