The role of TFE3, a metabolism-related transcription factor, in skeletal muscles.

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In this study, we investigated the roles of TFE3 in skeletal muscle, the main organ for energy metabolism, using transgenic mice overexpressing TFE3 in muscles. In TFE3 transgenic muscle, glycogen stores were more than 2-fold than wild-type, and this was associated with an upregulation of genes involved in glucose metabolism, specifically GLUT4, HK2 and GYS. Consequently, exercise endurance capacity was enhanced in this transgenic model. Furthermore, insulin sensitivity was enhanced in transgenic mice, and exhibited better improvement after 4 weeks of exercise training.These potential roles of TFE3 in regulating metabolic genes and glucose metabolism within skeletal muscle suggests that it may be used for treating metabolic diseases, as well as increasing endurance in sport.