Identification of the exercise not for bone formation but for bone absorption suppression and investigation of the underlying mechanisms

为了研究低强度振动对骨吸收和骨形成酶活性和基因表达的影响，我们培养了新生小鼠颅骨作为人骨模型。0。5和2。0-G振动加速度显著抑制破骨细胞酶活性，增加I型胶原的表达。我们还发现慢走产生0。腰部加速5-G或以上。因此，我们的研究结果表明，不仅是高强度的力量运动，如跳跃，而且频繁的步行会降低老年人腰部承重骨的骨吸收活性。

To investigate the effects of low intensity vibration on the enzyme activities and the gene expression for both bone absorption and formation, we cultivated neonatal mouse calvaria as human bone model. Mice calvaria treated with 0. 5-and 2. 0-G vibrational acceleration showed a significant inhibition of osteoclast enzyme activity and an increase of expression of type I collagen. We also found that slow walking generates 0. 5-G or more acceleration at the waist. Therefore, our results suggested that not only high-intensity strength exercises such as jumping, but frequent walking can decrease bone absorption activity in the weight bearing bone of the waist in elderly.