Effects of oral nutritional product on inflammatory bowel disease

溃疡性结肠炎和克罗恩病等顽固性炎症性肠病是结肠癌的重要危险因素，近年来结肠癌的发病频率逐渐增加，预计在未来几年将成为主要的死亡原因。因此，预防和改善症状是降低结肠癌发病率和提高患者生活质量的关键因素。我们观察了口服含有谷氨酰胺(G)、可溶性纤维(F)和寡糖(O)的三组分混合物(GFO合剂)对葡聚糖硫酸钠(DSS)诱导的小鼠溃疡性结肠炎模型的影响。此外，我们还研究了同时给予GFO混合物和β-羟基-β-甲基丁酸酯(HMB)的效果，HMB已被报道可防止荷瘤小鼠的体重下降(GFO HMB混合物)。结果表明，GFO合剂和GFO HMB合剂对DSS诱导的实验性结肠炎均有轻微的改善作用。然而，GFO HMB混合物比GFO混合物更有效。这些改善作用的机制之一可能涉及到结肠粘膜保护作用。

Intractable inflammatory bowel diseases such as ulcerative colitis and Crohn's disease are important risk factors for colon cancer, the frequency of which has increased progressively in recent years and is expected to become the leading cause of death in the next several years. Therefore, prevention and symptom improvement are key factors for decreasing colon cancer rates and improving the quality of life of these patients. We examined the effects of oral administration of a three-component mixture(GFO mixture) containing glutamine(G), soluble fiber(F) and oligosaccharide(O) on a dextran sulfate sodium(DSS)-induced ulcerative colitis model in mice. Furthermore, we investigated the effects of simultaneous administration of the GFO mixture and β-hydroxy-β-methylbutyrate(HMB), which has been reported to prevent weight loss in tumor-bearing mice(GFO+HMB mixture). As a result, both the GFO mixture and GFO+HMB mixture demonstrated slight amelioration of DSS-induced experimental colitis. However, the GFO+HMB mixture was more effective than GFO mixture. One of the mechanisms of these ameliorative effects may involve a colonic mucosal protective effect.