Novel insights into the effect protecting DNA from radiation-induced damage : identification of relevant factors involved in paracrine epithelial-mesenchymal cell interactions

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Normal epithelial and mesenchymal cells maintain paracrine cross-talk through secreted soluble factors. One of the observed outcomes of these intercellular interactions is the modulation(decrease) of the extent of radiation-induced DNA damage in both types of cells after reciprocal treatment with heterologous conditioned medium. Soluble factors secreted into medium are presumably a part of the conserved network of paracrine factors operating in a background mode that does not require any special pretreatment of the cells for induction. This study attempted to indentify such soluble factors particularly focusing on cytokines produced by primary thyroid epithelial cells and normal human fibroblasts as a model, and elucidation of the mechanism by which genotoxic insult is diminished.