Toxicity mechanism in hematopoietic stem/progenitor-derived signaling via aryl hydrocarbon receptors induced by benzene exposure

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We have discovered that, first, the simplest and fundamental aromatic hydrocarbon, benzene, can induce xenobiotic responses through the activation of the aryl hydrocarbon receptor(AhR) and that, second, the functional localization of AhRs affects niche function related to the developmental biological maintenance of undifferentiated progenitor cells. The benzene-induced xenobiotic responses through AhR activation at the primitive hematopoietic/progenitor level can be classified on the basis of the pattern of gene expression profile : benzene-induced common gene expression profiles(BICGEP), which are the specifically and commonly expressed profiles among the test mice in the same group, and benzene-induced stochastic gene expression profiles(BISGEP), which are the stochastic gene expression profiles that are probabilistically different in each of the test mice in the same group.