Analyses of methylarginines on the chemical communication between fetus and mother.

在本研究中，我们主要关注两点；1)进一步分析蛋白质精氨酸甲基化和阐明细胞内甲基精氨酸生产过程。2)甲基精氨酸及相关胺的胎-胎盘-母体药动学监测。综上所述，我们发现DAF-16的精氨酸甲基化调控秀丽隐杆线虫的寿命，游离甲基精氨酸可通过泛素-蛋白酶体系统和自噬体系统产生，并成功鉴定了几种参与母胎化学通讯的胺。

In the present study, we focused on two points;1) Further analyses of the protein arginine methylation and the elucidation of intracellular processes of methyl arginine production.2) Feto-placental-maternal pharmacokinetic monitoring of methyl arginines andrelated amines. In conclusion, we showed that the arginine methylationof DAF-16 regulates life-span of C. elegans and free-methylargines were generated through both ubiquitin-proteasome system and autophagosome system, and succeeded in identifications ofseveral amines involved in the feto-maternal chemical communications.