Development of Optically Active Amine Catalysts with a Propeller-like Chirality for Asymmetric Synthesis

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New asymmetric cycloisomerization reactions catalyzed by chiral amines have been developed to produce useful optically active furan- and pyran-containing heterobiaryl compounds with axial chirality. Novel chiral carbasugars, which would exhibit unique bioactivities, were also synthesized by using base-catalyzed rearrangement of endoperoxide. Furthermore, unprecedented optically active transition metal complexes with chirality at metal were prepared from a chiral tripodal tetradentate ligand based on tertially amine bearing three different coordination groups.