Construction and functionalization of molecular containers composed of peptidemimetic chiral bowls having C3-symmetry

以氨基酸为原料合成了碗状环状肽模拟物，并对其构象进行了表征。考察了这些环肽作为新型主体化合物的客体结合能力。在碗状环肽的边缘上引入可聚集的官能团后，通过NMR光谱观察到碗的聚集与不同浓度的碗。

We synthesized bowl-shaped cyclic peptidomimetic s from amino acids and elucidated their conformation. These cyclic peptides as new host compounds were examined their guest binding ability. After introduction of aggregable functional group on the rim of the bowl-shaped cyclic peptide, the aggregation of the bowls was observed by NMR spectra with varying concentration of the bowl.