Exploration of new antitoxic compounds neutralizing ciguatera fish poisoning from some southern medicinal plants

雪卡特拉鱼中毒(CFP)是一种因食用被有毒聚醚化合物、雪卡毒素(CTX)和毛霉毒素(MTX)污染的热带和亚热带珊瑚鱼而引起的鱼肉中毒。Garrec等人。有报道称，一些南方药用植物的提取物传统上用于治疗CFP，以防止环磷酰胺或短杆菌毒素(BTX)在体外产生的神经毒性。在此，我们通过体外神经毒性实验对从南方多种药用植物中分离得到的新型CFP抗毒化合物进行了研究。

Ciguatera fish poisoning(CFP) is an ichthyosarcotoxism caused by the consumption of tropical and subtropical coral fish contaminated with toxic polyether compounds, ciguatoxins(CTXs) and maitotoxin(MTX). Garrec et al. have reported that the extracts of some southern medicinal plants, traditionally used to treat CFP, to prevent in vitro neurotoxicity produced by CTX or brevetoxin(BTX). Here, we studied new CFP antitoxic compounds isolated from verious southern medicinal plants by using in vitro neurotoxicity assay.