Control of crystallization nucleation of organic compounds in recognizing of the importance of solution structure and its application for production of nano crystals

药物化合物的化学结构逐渐变得复杂和难以溶解。为了提高药物的生物利用度，必须通过控制结晶的成核步骤来制备药物的精细晶体。然而，成核的机制还没有得到很好的理解。在本研究中，我们首次发现，控制分子缔合结构的变化和控制分子的扩散是重要的控制成核。此外，我们尝试了一些方法来生产细晶体。

Chemical structure of pharmaceutical compounds evolves to become complex and hard to dissolve. To increase bioavailability of drugs, we must produce fine crystals of drugs by controlling the nucleation step of crystallization. However, the mechanism of nucleation has not been well understood. In the present study, we found for the first time that the control of the change of molecular associate structure and the control of diffusion of molecules are important to control nucleation. Furthermore, we attempted some processes to produce fine crystals.