Genetic study of TOR signaling pathway in fission yeast

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TOR is a conserved protein kinase, which forms two distinct complexes, TORC1 and TORC2. Fission yeast provides a powerful genetic system. Futhermore, the components of TOR signaling pathway are also conserved between fission yeast and mammalian. Thus fission yeast is an excellent model system to study the molecular mechanisms of TOR signaling. Fission yeast has two TOR, TOR1 and TOR2. In this study, novel genes that intereact with TORC1 or TORC2 have been obtained : mto1 and mtt1. mto1 was a evolutionarily conserved gene which encoded a novel protein of unknown function. mtt1 encoded a protein with a Zn-finger motif. Functional anayysis showed that it was involved in the metabolism of arginine.