Investigation and application of virus receptors for infection control by chemical probes regulating glycan function

为了阐明病毒受体的分子功能及其在病毒感染性疾病发生发展中的作用机制，我们制备了一种新的病毒糖蛋白受体单克隆抗体，为病毒糖蛋白受体的组织分布研究奠定了基础。利用竞争性抑制病毒-聚糖受体相互作用的人工聚糖和碳水化合物衍生物，建立了一种灵敏的病毒吸附特性分析方法。此外，我们新发现鞘糖脂参与病毒感染性疾病的进展。

In order to elucidate molecular function of virus receptors and mechanisms on progression of virus-infectious diseases, we generated a new monoclonal antibody specific for virus glycan receptor, which would contribute to elucidation of tissue distribution of the virus receptor. Artificial glycans and carbohydrate derivatives that competitively inhibited virus-glycan receptor interaction are used to establish a sensitive analysis method for virus adsorption properties. In addition, we newly found glycosphingolipids involved in progression of virus-infectious diseases.