Functional of a brain-specific mucin-type carbohydrate glycosyltransferase involved in neural development and apoptosis

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The purpose of this study is to clarify the roles of mucin-type carbohydrates and glycosyltransferases involved in their biosynthesis in neural development. We investigated the functions of WBSCR17, a brain-specific isozyme, and mucin-type carbohydrates in mouse embryonic carcinoma P19 cells, which can differentiate into neural cells, and human embryonic kidney HEK293T cells. Also the roles of WBSCR17 in neural differentiation in zebrafish were examined. Through these studies, we elucidated that WBCSR17 is involved in the neural development and membrane trafficking in the cells.