Regulation of CD44-hyaluronan interaction by SHAP and its role in inflammation

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CD44and its ligand hyaluronan emerge as important adhesion molecules for leucocyte infiltration in inflammatory response. We have found that the serum protein SHAP binds covalently to hyaluronan and enhances the adhesion of CD44-positive cells to hyalurona. In this project, we reveal that SHAP plays significant roles in in vivo inflammatory responses by using SHAP-deficient mice. Depending on the affected organ and disease model, the role of SHAP varies, either being inflammatory(such as in acute liver injury model) or being anti-inflammatory(such as in airway hyper-responsiveness model and intracerebral hemorrhage model).