Functional analysis of nuclear envelope targeting plasma membrane Proteins : using EGF family proteins

核膜靶向质膜蛋白的功能分析：使用 EGF 家族蛋白

• 批准号: 21570196
• 负责人: HIEDA Miki
• 金额: $ 3万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21570196/
• 关键词: 細胞構造・機能; 細胞核; 転写調節; 細胞遊走; 癌細胞遊走; amphiregulin; 核膜タンパク質; SUN; nesprin; LINC complex; H3K9me3; 細胞運動; 核膜; EGFファミリー

An EGF family member, amphiregulin, which has been suggested to play role(s) in breast cancer, is expressed on the cell surface in pro-form. Shedding stimuli result in release of soluble EGFR ligand and migration of the pro-form to the nuclear envelope. This study demonstrates that nuclear envelope-localized proAREG activates breast cancer cell migration and the activation of cell migration does not require EGFR function, but does occur concomitantly with an alteration of histone modification.

EGF家族成员，双调蛋白，已被认为在乳腺癌中发挥作用，在细胞表面以前体形式表达。脱落刺激导致可溶性EGFR配体的释放和前体形式向核膜的迁移。这项研究表明，核定位的proAREG激活乳腺癌细胞迁移和细胞迁移的激活不需要EGFR功能，但确实伴随着组蛋白修饰的改变发生。

项目成果

amphiregulin is translocated from the plasma membrane to the nuclear envelope and regulates cell migration

双调蛋白从质膜转移到核膜并调节细胞迁移

• 发表时间: 2011
• 作者: Miki Hieda;An EGFR ligand
• 通讯作者: An EGFR ligand

EGFファミリー増殖因子amphiregulinの核膜局在化による細胞遊走能の調節機構

EGF家族生长因子双调蛋白核膜定位调节细胞迁移能力的机制

• 发表时间: 2011
• 作者: 檜枝美紀;横山雄起;西岡優;田中ひさえ;東山繁樹;松浦成昭;松浦脩治
• 通讯作者: 松浦脩治

Trans-generational epigenetic regulation of C. elegans primordial germ cells.

• DOI: 10.1186/1756-8935-3-15
• 发表时间: 2010-08-12
• 期刊: Epigenetics & chromatin
• 影响因子: 3.9
• 作者: Furuhashi H;Takasaki T;Rechtsteiner A;Li T;Kimura H;Checchi PM;Strome S;Kelly WG
• 通讯作者: Kelly WG

Nuclear envelope localized EGF receptor ligand, amphiregulin activates the cell migration via chromatin reorganization

核膜定位的 EGF 受体配体，双调蛋白通过染色质重组激活细胞迁移

• 发表时间: 2011
• 作者: Onishi M;Koga T;Hirata A;Nakamura T;Asakawa H;Shimoda C;Bahler J;Wu JQ;Takegawa K;Tachikawa H;Pringle JR;Fukui Y;Miki Hieda
• 通讯作者: Miki Hieda

Roles of histone H3K9 methyltransferases during Drosophila spermatogenesis

• DOI: 10.1007/s10577-012-9276-1
• 发表时间: 2012-04
• 期刊: Chromosome Research
• 影响因子: 2.6
• 作者: Yuta Ushijima;Y. Inoue;Takahiro Konishi;Daishi Kitazawa;H. Yoshida;Kouhei Shimaji;H. Kimura;M. Yamaguchi