Analysis of mechanisms to regulate oxidative stress response by glyceraldehyde-3-phosphate dehydrogenase

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As environmental conditions are always fluctuating, it is most important function for organisms to sense the changes and protect themselves. I, in this research, biochemically analyzed two signal transduction pathways that control stress resistance or proliferation/growth. Moreover, I elucidated function of a glycolytic enzyme GAPDH on the pathways. In conclusion, GAPDH has functions as a sensor of oxidative stress and a master regulator of adaptation to the stress conditions, in addition to the classical function.